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KMID : 0378019670100060055
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New Medical Journal
1967 Volume.10 No. 6 p.55 ~ p.68
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Studies on the Mechanism of Acceleration of Erythrocyte Sedimentation Rate by Necrotic Tissue Extract
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Abstract
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The author prepared saline extracts from autolized heart tissue and various tissues rendered necrotic by ligating the arteries suppling blood to them. He investigated changes in ESR in the rabbits administered with the extracts, fractions of the necrotic liver or kidney tissue extract, and studied in vitro and in vivo the mechanism of the acceleration of ESR with the necrotic liver tissue extract.
The results thus.obtained are as follows:
1. The autolized heart tissue extract and the extract of the necrotic liver, spleen, or kidney tissue can produce high ESR when they are injected intravenously to normal animals.
2. The ability to accelerate.ESR of the necrotic liver and kidney tissue extracts seems to be attributable to the function of their alpha - and gamma globulin fractions.
3. The necrotic liver or kidney tissue extracts has no effect on ESR in vitro, and it seems, therefore, to have no direct connection with the mechanism of the acceleration of ESR by the extracts.
4. The`hematocrit values and fibrinogen contents in plasm in the rabbits administered with the necrotic liver or kidney tissue extract show no significant change. This suggests that the two factors play no important part in the acceleration of ESR by the necrotic tissue extracts.
5. The sera obtained from the rabbits administered with the necrotic liver or. kidney tissue extract are found to be effective in increasing ESR both in vitro and in vivo studies. This may indicate that the sera may contain a certain endogenous active substance which can accelerate ESR. This substance, however, can not be demonstrated by ordinary electrophoretic fractionation of the sera. -
6. On the basis of the above the author would like to conclude; that increased ESR associated with destructive injuries to the tissue of inflammatory or non-inflammatory origin might be attributed to the appearance in the circulating blood of the endogenous substance which may be produced in certain tissues or cells by the stimulation of the homologous material liverated from the injured tissue and carried to the blood way.
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